SCHEMBL8440409

SCHEMBL8440409

CN(c1ccncc1)c1csc2ccncc12

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.43
CHRM5 P08912 1/20 0.38
CHKA P35790 1/20 0.38
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
LATS1 O95835 3/20 0.33
LATS2 Q9NRM7 3/20 0.33
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
NPC1 O15118 1/20 0.32
GFER P55789 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8440253 0.87 CHRM5 (0.38) CYP2A6CHRM5CHKAMAPTSMN1; SMN2
SCHEMBL8039461 0.84 MAPT (0.39) CYP2A6CHRM5CHKAMAPTSMN1; SMN2
SCHEMBL31751996 0.83 CYP2A6 (0.47) CYP2A6CHRM5CHKAMAPTSMN1; SMN2
Hydrochloric Acid SCHEMBL8039050 0.83 MAPT (0.38) CYP2A6CHRM5CHKAMAPTSMN1; SMN2
SCHEMBL8440389 0.80 CYP2A6 (0.40) CYP2A6CHRM5CHKALATS1LATS2
SCHEMBL8442574 0.78 CYP2A6 (0.41) CYP2A6CHRM5CHKASMN1; SMN2
SCHEMBL8438931 0.78 CYP2A6 (0.41) CYP2A6LATS1LATS2
SCHEMBL8051671 0.76 GRM1 (0.34) CHRM5CHKAMAPTSMN1; SMN2
SCHEMBL8054092 0.76 CHKA (0.44) CYP2A6CHRM5CHKAMAPTPTGS2
SCHEMBL8051689 0.76 GAK (0.40) CHRM5CHKAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5856335-A GLYCINE PARTIAL AGONISTS. HOECHST MARION ROUSSEL, INC. (US) 1999-01-05 US disclosed
US-5519032-A ANTIDEPRESSANTS, ANXIOLYTICS, ANTIEMETICS, ANTIPSYCHOTIC HOECHST MARION ROUSSEL INC. (US) 1996-05-21 US disclosed
EP-0581106-A1 Substituted aminothienopyridines, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1994-02-02 EP disclosed
US-5252581-A Modulators of neurotransmitters HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1993-10-12 US disclosed