Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.61 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.61 |
| ▸ | VDR | P11473 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | CDC25A | P30304 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | PGR | P06401 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281111 | 0.87 | VDR (0.68) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL11352175 | 0.82 | MAPT (0.68) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL4974568 | 0.81 | VDR (0.70) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL3698818 | 0.81 | MAPT (0.69) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL260762 | 0.81 | MAPT (0.69) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL6842113 | 0.81 | MAPT (0.69) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL10034118 | 0.81 | MAPT (0.69) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL9330205 | 0.81 | MAPT (0.71) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL4979145 | 0.80 | CDC25A (0.60) | ADORA3SLC6A2AGTR1VDRMAPT | |
| SCHEMBL10937380 | 0.80 | ADORA3 (0.75) | ADORA3SLC6A2AGTR1VDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |