Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.58 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442975 | 0.81 | CRBN (0.55) | DDB1CRBNBRD4CREBBPMAPT | |
| SCHEMBL9261121 | 0.80 | DDB1 (0.55) | DDB1CRBNBRD4CREBBPMAPT | |
| SCHEMBL8438332 | 0.77 | PDE4A (0.46) | DDB1CRBNBRD4CREBBPHTR1A | |
| SCHEMBL9251370 | 0.76 | DDB1 (0.55) | DDB1CRBNMAPTALDH1A1ALOX5 | |
| SCHEMBL17276398 | 0.76 | ALDH1A1 (0.36) | DDB1CRBNCREBBPMAPTALDH1A1 | |
| SCHEMBL9253505 | 0.76 | DDB1 (0.55) | DDB1CRBNMAPTALDH1A1ALOX5 | |
| SCHEMBL17276655 | 0.75 | ALDH1A1 (0.41) | MAPTALDH1A1 | |
| SCHEMBL11036165 | 0.75 | CRBN (0.47) | DDB1CRBNBRD4CREBBPMAPT | |
| SCHEMBL8439360 | 0.75 | CRBN (0.47) | DDB1CRBNBRD4CREBBPMAPT | |
| SCHEMBL8522217 | 0.75 | CRBN (0.47) | DDB1CRBNBRD4CREBBPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015179293-A1 | SMALL MOLECULE ACTIVATORS AND INHIBITORS OF LECITHIN: CHOLESTEROL ACYLTRANSFERASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-11-26 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |
| WO-1995002579-A1 | SUBSTITUTED AZETIDINONE AMIDE DERIVATIVES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | ZENECA LIMITED (GB) | 1995-01-26 | — | — | WO | disclosed |