Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443344 | 0.92 | LMNA (0.46) | KMT2APOLBALDH1A1MEN1 | |
| SCHEMBL8440358 | 0.91 | PLA2G7 (0.44) | KMT2APOLBALDH1A1MEN1FPR2 | |
| SCHEMBL8443114 | 0.90 | KMT2A (0.47) | KMT2APOLBALDH1A1MEN1ATM | |
| SCHEMBL8439155 | 0.89 | PLAAT3 (0.47) | KMT2APOLBALDH1A1 | |
| SCHEMBL8438577 | 0.89 | PLAAT3 (0.47) | KMT2APOLBALDH1A1 | |
| SCHEMBL8438842 | 0.89 | PLAAT3 (0.47) | KMT2APOLBALDH1A1 | |
| SCHEMBL8440368 | 0.89 | PLAAT3 (0.47) | KMT2APOLBALDH1A1 | |
| SCHEMBL8590720 | 0.84 | MAPT (0.43) | ALDH1A1 | |
| SCHEMBL8591631 | 0.84 | HRH3 (0.40) | POLBALDH1A1 | |
| SCHEMBL8440280 | 0.83 | TRPV1 (0.50) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| US-5885931-A | GLYCOSIDE, ETHOXYLATED ALKYLAMINE, POLYOXYALKYLENE ALKYLPHENOL PHOSPHORIC ACID ESTER, GLYCOL, WATER | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1999-03-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |
| EP-0299654-B1 | COMPOSITION AND USE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-27 | — | — | EP | disclosed |
| EP-0299654-A2 | Composition and use | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-01-18 | — | — | EP | disclosed |