Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 3/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 3/20 | 0.40 |
| ▸ | GRK1 | Q15835 | 2/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443783 | 0.81 | BCL2L1 (0.41) | BCL2L1CHUKCLK1CLK2HIPK1 | |
| SCHEMBL8488240 | 0.77 | CHUK (0.48) | CHUK | |
| SCHEMBL8480944 | 0.76 | PDK1 (0.47) | CHUK | |
| SCHEMBL8443816 | 0.76 | MAPK8 (0.52) | BCL2L1CLK2HIPK2CLK4ROCK2 | |
| SCHEMBL8443752 | 0.75 | ACVR1 (0.48) | CHUKCLK2HIPK1HIPK2CLK4 | |
| SCHEMBL8445036 | 0.71 | MAPK8 (0.39) | CHUKCLK1CLK2HIPK1HIPK2 | |
| SCHEMBL8443803 | 0.70 | CHUK (0.39) | CHUK | |
| SCHEMBL30248664 | 0.70 | IMPDH2 (0.51) | CHUKGRK2AKT1AKT2 | |
| SCHEMBL8480893 | 0.70 | BRD4 (0.38) | CHUKCLK1CLK2HIPK1HIPK2 | |
| SCHEMBL13505521 | 0.70 | BRD4 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |
| EP-1749829-A1 | JNK inhibitors | Eisai London Research Laboratories Limited (GB) | 2007-02-07 | — | — | EP | disclosed |