Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.48 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.48 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 12/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13505283 | 0.85 | BMPR1B (0.47) | ACVR1BMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8488240 | 0.83 | CHUK (0.48) | ACVR1BMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8480944 | 0.82 | PDK1 (0.47) | ACVR1BMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL3348977 | 0.76 | HTR6 (0.48) | ACVR1BMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8445006 | 0.75 | BCL2L1 (0.45) | CHUKCLK2HIPK1HIPK2CLK4 | |
| SCHEMBL8445783 | 0.74 | CHUK (0.39) | ACVR1BMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL13746422 | 0.74 | ACVR1 (0.53) | ACVR1BMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8443803 | 0.73 | CHUK (0.39) | ACVR1BMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL3351151 | 0.73 | MAPK8 (0.57) | — | |
| SCHEMBL8445036 | 0.72 | MAPK8 (0.39) | ACVR1BMPR1BKDRBMPR1AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-A1 | JNK inhibitors | Eisai London Research Laboratories Limited (GB) | 2007-02-07 | — | — | EP | disclosed |