Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 15/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480944 | 0.84 | PDK1 (0.47) | CHUKBMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8443752 | 0.83 | ACVR1 (0.48) | CHUKBMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8445006 | 0.77 | BCL2L1 (0.45) | CHUK | |
| SCHEMBL4403657 | 0.77 | BRD4 (0.49) | LRRK2PIM1AURKBPIK3CA | |
| SCHEMBL13746422 | 0.76 | ACVR1 (0.53) | CHUKLRRK2BMPR1BKDRBMPR1A | |
| SCHEMBL8445783 | 0.76 | CHUK (0.39) | CHUKBMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8471885 | 0.76 | CHUK (0.39) | CHUKLRRK2BMPR1BKDRBMPR1A | |
| SCHEMBL8443803 | 0.76 | CHUK (0.39) | CHUKBMPR1BKDRBMPR1AACVRL1 | |
| SCHEMBL8443781 | 0.75 | BRD4 (0.44) | CHUK | |
| SCHEMBL17211630 | 0.74 | BRD4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |