Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 13/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8445293 | 0.87 | CTSL (0.75) | CTSLCTSB | |
| SCHEMBL27950773 | 0.85 | CTSL (1.00) | CTSLALDH1A1LMNAGAAHTT | |
| SCHEMBL6338417 | 0.83 | CTSL (0.64) | CTSLCTSB | |
| SCHEMBL8445279 | 0.81 | CTSL (0.65) | CTSLCTSB | |
| SCHEMBL6337559 | 0.80 | CTSL (0.80) | CTSLCTSB | |
| SCHEMBL2675161 | 0.80 | CTSL (0.80) | CTSLCTSB | |
| SCHEMBL8445285 | 0.78 | CTSL (0.60) | CTSLCTSB | |
| SCHEMBL8445278 | 0.78 | CTSL (0.59) | CTSLCTSB | |
| SCHEMBL2675409 | 0.78 | CTSL (0.86) | CTSLCTSB | |
| SCHEMBL8589273 | 0.76 | CTSL (0.63) | CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495023-B2 | Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-02-24 | — | — | US | disclosed |
| US-20040014801-A1 | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014801-A1 | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use | CTSB, CTSS, CTSL | CTSL 3/4885ALDH1A1 1366/4885LMNA 2675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.