Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 14/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443582 | 0.81 | CHUK (0.33) | CHUKGSK3BGSK3AKDRACVR1 | |
| SCHEMBL15333327 | 0.80 | ELANE (0.39) | GSK3BGSK3AKDRPDGFRB | |
| SCHEMBL14884085 | 0.76 | FFAR1 (0.39) | GSK3BGSK3AKDRPDGFRB | |
| SCHEMBL8488240 | 0.76 | CHUK (0.48) | CHUKKDRACVR1BMPR1BBMPR1A | |
| SCHEMBL20610615 | 0.75 | GSK3A (0.37) | GSK3BGSK3AKDRPDGFRB | |
| SCHEMBL8480944 | 0.75 | PDK1 (0.47) | CHUKGSK3BKDRACVR1BMPR1B | |
| SCHEMBL8443752 | 0.74 | ACVR1 (0.48) | CHUKKDRACVR1BMPR1BBMPR1A | |
| SCHEMBL731495 | 0.71 | MAP3K14 (0.50) | ACVR1 | |
| SCHEMBL13746422 | 0.70 | ACVR1 (0.53) | CHUKGSK3BKDRACVR1BMPR1B | |
| SCHEMBL21142655 | 0.69 | LPL (0.42) | KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |
| EP-1749829-A1 | JNK inhibitors | Eisai London Research Laboratories Limited (GB) | 2007-02-07 | — | — | EP | disclosed |