Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8444221 | 0.86 | CYP3A4 (0.44) | CYP3A4CYP2D6MAPTALDH1A1TDP1 | |
| SCHEMBL8073894 | 0.81 | CTSZ (0.45) | MAPTALDH1A1GAAKMT2ATHRA | |
| SCHEMBL8068695 | 0.80 | ADRA1A (0.42) | ADRA2AADRA1DADRA1AADRA1BTHRA | |
| SCHEMBL8446994 | 0.80 | RAB9A (0.53) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8073502 | 0.76 | TTR (0.51) | MAPTALDH1A1GAATTR | |
| SCHEMBL8446364 | 0.76 | CA1 (0.55) | MAPTALDH1A1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL8068490 | 0.76 | TTR (0.44) | MAPTALDH1A1KMT2ASMN1; SMN2THRA | |
| SCHEMBL11884885 | 0.72 | CYP3A4 (1.00) | CYP3A4CYP2D6MAPTALDH1A1TDP1 | |
| SCHEMBL7995261 | 0.72 | TTR (0.61) | ALDH1A1TDP1TTR | |
| SCHEMBL8059681 | 0.72 | TTR (0.45) | MAPTGAAGFERSMN1; SMN2TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |