Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070681 | 0.86 | MAPT (0.42) | RAB9AALDH1A1NPC1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8446098 | 0.85 | RAB9A (0.45) | RAB9AALDH1A1NPC1HPGDSMN1; SMN2 | |
| SCHEMBL8073894 | 0.82 | CTSZ (0.45) | RAB9AALDH1A1NPC1HPGDKDM4E | |
| SCHEMBL8446993 | 0.80 | CYP3A4 (0.55) | ALDH1A1SMN1; SMN2HSD17B10ALOX15MAPT | |
| SCHEMBL8446364 | 0.79 | CA1 (0.55) | RAB9AALDH1A1NPC1HPGDSMN1; SMN2 | |
| SCHEMBL8059524 | 0.78 | KDM4E (0.50) | ALDH1A1SMN1; SMN2KDM4EMAPTKMT2A | |
| SCHEMBL7995261 | 0.78 | TTR (0.61) | ALDH1A1POLBPKMTTR | |
| SCHEMBL8073502 | 0.77 | TTR (0.51) | ALDH1A1MAPTPOLBPKMTTR | |
| SCHEMBL8073710 | 0.77 | SMN1; SMN2 (0.38) | ALDH1A1HPGDSMN1; SMN2MAPTKMT2A | |
| SCHEMBL8068490 | 0.76 | TTR (0.44) | ALDH1A1SMN1; SMN2MAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |