SCHEMBL8449504

CC(C)CN(C[C@H](CCc1ccccc1)C(=O)Oc1ccc2c(c1)CCC2)C(=O)N[C@H](C(=O)O)C(Cc1ccccc1)c1ccc2ccccc2c1

nearest known ligand 0.40

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	MME	P08473	6/20	0.40

▸	ACE	P12821	5/20	0.40

▸	PPARG	P37231	3/20	0.35

▸	PPARD	Q03181	3/20	0.35

▸	UTS2R	Q9UKP6	3/20	0.34

▸	MMEL1	Q495T6	1/20	0.33

▸	PTGES	O14684	1/20	0.33

▸	PPARA	Q07869	1/20	0.33

▸	MMP3	P08254	1/20	0.32

▸	RXRA	P19793	1/20	0.32

▸	RXRB	P28702	1/20	0.32

▸	RXRG	P48443	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8447132	0.93	MME (0.40)	MMEACEPPARGPPARDMMEL1
SCHEMBL8447129	0.88	MME (0.41)	MMEACEPPARGPPARDMMEL1
SCHEMBL8450833	0.87	MME (0.42)	MMEACEPPARGPPARDMMEL1
SCHEMBL7572570	0.85	MME (0.58)	MMEACE
SCHEMBL7572563	0.85	MME (0.58)	MMEACE
SCHEMBL8446482	0.85	MME (0.49)	MMEACEUTS2R
SCHEMBL8449483	0.84	MME (0.42)	MMEACEUTS2RPTGESMMP3
SCHEMBL7574128	0.83	MME (0.53)	MMEACEPPARGPPARDMMEL1
SCHEMBL7570073	0.83	MME (0.53)	MMEACEPPARGPPARDMMEL1
SCHEMBL8447142	0.82	MME (0.47)	MMEACEUTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5968980-A	ENDOPEPTIDASE 24.11 INHIBITORS	SANTEN PHARMACEUTICAL CO., LTD. (JP)	1999-10-19	—	—	US	disclosed