SCHEMBL8450833

CC(C)CN(C[C@H](Cc1ccccc1)C(=O)Oc1ccc2c(c1)CCC2)C(=O)N[C@H](C(=O)O)C(Cc1ccccc1)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	MME	P08473	5/20	0.42

▸	ACE	P12821	4/20	0.42

▸	MMEL1	Q495T6	1/20	0.40

▸	PPARG	P37231	4/20	0.37

▸	PPARD	Q03181	3/20	0.37

▸	FDFT1	P37268	2/20	0.36

▸	ACACB	O00763	1/20	0.35

▸	ACACA	Q13085	1/20	0.35

▸	PTGES	O14684	1/20	0.34

▸	PPARA	Q07869	1/20	0.34

▸	NLRP3	Q96P20	2/20	0.34

▸	MCHR1	Q99705	1/20	0.34

▸	MAPK14	Q16539	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8447129	0.95	MME (0.41)	MMEACEMMEL1PPARGPPARD
SCHEMBL8447132	0.94	MME (0.40)	MMEACEMMEL1PPARGPPARD
SCHEMBL8449913	0.90	MME (0.40)	MMEACEMMEL1PPARGPPARD
SCHEMBL8450138	0.89	MMEL1 (0.47)	MMEACEMMEL1PPARGPPARD
SCHEMBL7569417	0.88	MME (0.56)	MMEACEMMEL1PPARGPPARD
SCHEMBL7569408	0.88	MME (0.56)	MMEACEMMEL1PPARGPPARD
SCHEMBL8449504	0.87	MME (0.40)	MMEACEMMEL1PPARGPPARD
SCHEMBL8450828	0.85	MME (0.47)	MMEACEMMEL1PPARGPPARD
SCHEMBL7566393	0.83	MME (0.55)	MMEACEMMEL1PPARGPPARD
SCHEMBL7566387	0.83	MME (0.55)	MMEACEMMEL1PPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5968980-A	ENDOPEPTIDASE 24.11 INHIBITORS	SANTEN PHARMACEUTICAL CO., LTD. (JP)	1999-10-19	—	—	US	disclosed