SCHEMBL8449765

SCHEMBL8449765

COc1ccc2c(c1)c(O)nn2Cc1c(F)cccc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.53
MEN1 O00255 1/20 0.53
SLC22A12 Q96S37 2/20 0.48
BUB1 O43683 1/20 0.47
ALDH1A1 P00352 3/20 0.44
LMNA P02545 1/20 0.43
RORC P51449 2/20 0.43
PLA2G2A P14555 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.42
RAB9A P51151 1/20 0.42
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
PTGER3 P43115 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8444643 0.92 SLC22A12 (0.48) KMT2AMEN1SLC22A12RORCPLA2G2A
SCHEMBL8522107 0.87 CFD (0.40) KMT2AMEN1PLA2G2A
SCHEMBL8446733 0.81 PLA2G2A (0.48) PLA2G2A
SCHEMBL6966885 0.79 KDM4E (0.50) KMT2AMEN1BUB1LMNASMN1; SMN2
SCHEMBL8443748 0.78 PLA2G2A (0.52) KMT2AMEN1ALDH1A1LMNAPLA2G2A
SCHEMBL8448659 0.78 CNR1 (0.52) KMT2AMEN1BUB1ALDH1A1LMNA
SCHEMBL8448874 0.77 MAPT (0.49) KMT2AMEN1ALDH1A1LMNAPLA2G2A
SCHEMBL8310022 0.77 CCR2 (0.50) KMT2AMEN1ALDH1A1LMNACYP1A2
SCHEMBL8449970 0.76 CYP1A2 (0.49) KMT2AMEN1BUB1ALDH1A1LMNA
SCHEMBL8627206 0.75 BUB1 (0.44) KMT2ABUB1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888307-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-01-07 EP claimed
US-5776932-A ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) 1998-07-07 US claimed
WO-1997034874-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1997-09-25 WO claimed
EP-0888307-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-01-07 EP disclosed
US-5776932-A ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) 1998-07-07 US disclosed
WO-1997034874-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1997-09-25 WO disclosed