Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | USP2 | O75604 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8457471 | 0.76 | HIF1A (0.38) | ALDH1A1HSD17B10KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL9697111 | 0.76 | NPC1 (0.46) | TSHRALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL356141 | 0.75 | TNF (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2ACFTR | |
| SCHEMBL5761994 | 0.75 | ADORA3 (0.40) | TSHRALDH1A1HSD17B10USP2KDM4E | |
| SCHEMBL9696683 | 0.74 | GRIN1 (0.37) | ALDH1A1HSD17B10KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL4737092 | 0.71 | SLC9A1 (0.34) | ALDH1A1KDM4EATMSMN1; SMN2MAPK1 | |
| SCHEMBL944723 | 0.71 | TDP1 (0.51) | TSHRALDH1A1SMN1; SMN2MAPK1HTT | |
| SCHEMBL1381878 | 0.71 | SLC9A1 (0.44) | TSHRALDH1A1HSD17B10USP2KDM4E | |
| SCHEMBL2103982 | 0.71 | POLB (0.39) | TSHRALDH1A1KDM4EATMMAPK1 | |
| SCHEMBL945956 | 0.70 | TNF (0.50) | TSHRALDH1A1KDM4ESMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1143856-C | Novel substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) [1,4] diazepan-1-yl)-1-(aryl) butyl) benzamides useful for treatment of allergic diseases | ���µ�˹ҩ�﹫˾ | 2004-03-31 | — | — | CN | disclosed |
| CN-1115341-C | Novel substituted N-methyl-N- (4- (4- (1H-benzimidazol-2-ylamino) piperidin-1-yl) -2- (aryl) butyl) benzamides for the treatment of allergic diseases | AVENTIS PHARMACEUTICALS CORP (US) | 2003-07-23 | — | — | CN | disclosed |
| CN-1211248-A | Novel substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) [1,4] diazepan-1-yl)-1-(aryl) butyl) benzamides useful for treatment of allergic diseases | HOECHST MARION ROUSSEL INC (US) | 1999-03-17 | — | — | CN | disclosed |
| CN-1211246-A | Novel substituted N-methyl-N-(4-(1H-benzimidazol-2-yl-amino) piperidin-1-yl)-2-(aryl) butyl) benzamides useful for treatment of allergic diseases | HOECHST MARION ROUSSEL INC (US) | 1999-03-17 | — | — | CN | disclosed |
| EP-0888336-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997030989-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-28 | — | — | WO | disclosed |