Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13272514 | 0.88 | LMNA (0.40) | LMNAGLANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL845735 | 0.83 | POLB (0.45) | MAPTPOLBKMT2AALDH1A1 | |
| SCHEMBL845367 | 0.79 | ALDH1A1 (0.47) | MAPTHTTPOLBTDP1KMT2A | |
| SCHEMBL845008 | 0.78 | ALDH1A1 (0.54) | LMNAMAPTHTTPOLBTDP1 | |
| SCHEMBL845300 | 0.77 | CYP2C9 (0.54) | MAPTHTTALDH1A1 | |
| SCHEMBL844980 | 0.76 | ALDH1A1 (0.45) | MAPTHTTPOLBKMT2AALDH1A1 | |
| SCHEMBL845421 | 0.76 | ALDH1A1 (0.42) | NPC1MAPTHTTPOLBKMT2A | |
| SCHEMBL845422 | 0.76 | KMT2A (0.46) | LMNANPC1MAPTHTTPOLB | |
| SCHEMBL845013 | 0.75 | CYP2C9 (0.46) | LMNAMAPTHTTALDH1A1 | |
| SCHEMBL845338 | 0.75 | RHOC (0.48) | NPC1POLBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |