Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13272510 | 0.87 | MAPK1 (0.39) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL13272433 | 0.86 | MAPK1 (0.38) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL845258 | 0.81 | MAPK1 (0.60) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL845364 | 0.78 | LMNA (0.52) | NPC1LMNA | |
| SCHEMBL845003 | 0.77 | F2 (0.58) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL845030 | 0.77 | ALDH1A1 (0.49) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL844884 | 0.75 | HTT (0.48) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL10299164 | 0.75 | NPC1 (0.76) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL10281278 | 0.75 | NPC1 (0.76) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL845227 | 0.75 | NPC1 (0.76) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |