Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614 | 0.82 | DRD4 (0.45) | PIK3CDALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL3711668 | 0.81 | MTNR1A (0.39) | PIK3CDHIF1ADRD4DRD3L3MBTL1 | |
| SCHEMBL3705670 | 0.76 | PIK3CD (0.43) | PIK3CDALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL863898 | 0.75 | USP9X (0.36) | GHSRPIK3CDMAPTTP53L3MBTL1 | |
| SCHEMBL3716002 | 0.74 | TP53 (0.37) | GHSRALDH1A1CYP3A4MAPTTP53 | |
| SCHEMBL845139 | 0.72 | PIK3CD (0.53) | PIK3CDCNR1ALDH1A1MAPTTP53 | |
| SCHEMBL716341 | 0.71 | L3MBTL1 (0.50) | PIK3CDCNR1ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL24597723 | 0.70 | MEN1 (0.47) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL29750489 | 0.70 | MEN1 (0.47) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL20563014 | 0.69 | MEN1 (0.42) | PIK3CDALDH1A1MAPTTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396315-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092340-A1 | FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-08-19 | — | — | WO | disclosed |