Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631029 | 0.89 | GRM5 (0.53) | GRM5ALDH1A1HSD17B10CYP1A2L3MBTL1 | |
| SCHEMBL11008836 | 0.84 | TP53 (0.52) | L3MBTL1PTPN11PDK1PDK2PDK3 | |
| SCHEMBL21715154 | 0.82 | GRM5 (0.58) | GRM5ALDH1A1HSD17B10CYP1A2L3MBTL1 | |
| SCHEMBL13400502 | 0.81 | KCNK3 (0.50) | L3MBTL1POLBEGFRKDM4EMEN1 | |
| SCHEMBL15612045 | 0.81 | PTPN11 (0.71) | GRM5ALDH1A1HSD17B10CYP1A2L3MBTL1 | |
| SCHEMBL10191902 | 0.81 | ALDH1A1 (0.59) | GRM5ALDH1A1HSD17B10CYP1A2L3MBTL1 | |
| SCHEMBL31536232 | 0.81 | EGFR (0.49) | L3MBTL1PTPN11PDK1PDK2PDK3 | |
| SCHEMBL2889973 | 0.81 | EGFR (0.49) | L3MBTL1PTPN11PDK1PDK2PDK3 | |
| SCHEMBL13132849 | 0.80 | SIRT1 (0.49) | ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL13132736 | 0.80 | NPC1 (0.46) | ALDH1A1PTPN11RAB9APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433931-B2 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2016-11-02 | — | — | EP | disclosed |
| EP-2433931-B2 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2016-11-02 | — | — | EP | disclosed |
| US-8609841-B2 | Method for the preparation of erlotinib | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2013-12-17 | — | — | US | disclosed |
| EP-2433931-B1 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2013-08-21 | — | — | EP | disclosed |
| EP-2433931-B1 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2013-08-21 | — | — | EP | disclosed |
| US-20120095228-A1 | METHOD FOR THE PREPARATION OF ERLOTINIB | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-04-19 | — | — | US | disclosed |
| EP-2433931-A1 | New method for the preparation of erlotinib | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433931-A1 | New method for the preparation of erlotinib | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2012-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095228-A1 | METHOD FOR THE PREPARATION OF ERLOTINIB | EGFR, ABL1, ERBB2 | GRM5 2904/4885ALDH1A1 823/4885HSD17B10 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.