Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL572980 | 0.80 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL342628 | 0.80 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL10701087 | 0.78 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL10618827 | 0.77 | MEN1 (0.43) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL4439152 | 0.74 | MEN1 (0.53) | MEN1LMNAKMT2A | |
| Ethylene Glycol SCHEMBL6033397 | 0.74 | TSHR (0.36) | — | |
| Tromethamine SCHEMBL442155 | 0.73 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL22471999 | 0.73 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1585499 | 0.73 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193959 | 0.73 | MEN1 (0.83) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882755-A1 | Radially layered copoly (amidoamineorganosilicon) dendrimers | DOW CORNING CORPORATION (US) | 1998-12-09 | — | — | EP | claimed |
| US-20240019792-A1 | TONER | CANON KABUSHIKI KAISHA (JP) | 2024-01-18 | — | — | US | disclosed |
| WO-2021074767-A1 | DIRT PICK UP RESISTANT ADDITIVE | CLARIANT INDIA LIMITED (IN) | 2021-04-22 | — | — | WO | disclosed |
| US-10066060-B2 | Production method for high-purity organosilicon compound | DOW CORNING TORAY CO., LTD. (JP) | 2018-09-04 | — | — | US | disclosed |
| EP-2434342-B1 | Method for producing curable composition for imprints | FUJIFILM CORP (JP) | 2018-06-20 | — | — | EP | disclosed |
| US-20170176642-A1 | CONTACT LENS MATERIAL | DEALTFORCE LIMITED (GB) | 2017-06-22 | — | — | US | disclosed |
| EP-3113938-A1 | CONTACT LENS MATERIAL | Dealtforce Limited (GB) | 2017-01-11 | — | — | EP | disclosed |
| US-20150376346-A1 | Production Method For Manufacturing High-Purity Organosilicon Compound | DOW TORAY CO., LTD. (JP) | 2015-12-31 | — | — | US | disclosed |
| EP-2940062-A1 | METHOD FOR MANUFACTURING HIGH-PURITY ORGANOSILICON COMPOUND | Dow Corning Toray Co., Ltd. (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2940063-A1 | MANUFACTURING METHOD FOR HIGH-PURITY GLYCEROL DERIVATIVE-MODIFIED SILICONE | Dow Corning Toray Co., Ltd. (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-1616557-A2 | Cosmetic composition containing a selected silicone polymer and a film-forming agent | L'OREAL (FR) | 2006-01-18 | — | — | EP | disclosed |
| EP-1595524-A1 | Nail composition comprising a sequenced polymer and a plastifying agent | L'OREAL (FR) | 2005-11-16 | — | — | EP | disclosed |
| EP-1421928-A2 | Nail enamel composition containing a block copolymer | L'OREAL (FR) | 2004-05-26 | — | — | EP | disclosed |
| US-6503679-B2 | Color toner for developing an electrostatic image | MINOLTA CO., LTD. (JP) | 2003-01-07 | — | — | US | disclosed |
| US-20020042013-A1 | Color toner for developing an electrostatic image | MINOLTA CO., LTD. (JP) | 2002-04-11 | — | — | US | disclosed |
| US-6335134-B1 | USED IN AN ELECTROPHOTOGRAPHY | MINOLTA CO., LTD. (JP) | 2002-01-01 | — | — | US | disclosed |
| EP-1162943-A1 | NON-STINGING COATING COMPOSITION | 3M Innovative Properties Company (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056280-A1 | NON-STINGING COATING COMPOSITION | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2000-09-28 | — | — | WO | disclosed |
| EP-0629628-A2 | Surface-active siloxane coating compounds and their use in coatings | OSI SPECIALTIES, INC. (US) | 1994-12-21 | — | — | EP | disclosed |
| US-5359109-A | Waterproof coating | OSI SPECIALTIES, INC. (US) | 1994-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376346-A1 | Production Method For Manufacturing High-Purity Organosilicon Compound | OR51E2, OR10J3, OSTC | MEN1 1240/4885LMNA 1246/4885KMT2A 3305/4885 |
| US-10066060-B2 | Production method for high-purity organosilicon compound | OR51E2, SI, VIP | MEN1 1346/4885LMNA 1539/4885KMT2A 3655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.