Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845097 | 0.87 | NAMPT (0.39) | NAMPTPDE3BPDE3AEPHX2LMNA | |
| SCHEMBL845214 | 0.82 | ITGB1 (0.39) | NAMPTPDE3BPDE3AEPHX2LMNA | |
| SCHEMBL845331 | 0.79 | PTPN1 (0.41) | NAMPTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL844741 | 0.78 | ITGB1 (0.39) | NAMPTPDE3BPDE3AEPHX2LMNA | |
| SCHEMBL13272184 | 0.77 | PDE3B (0.34) | NAMPTPDE3BPDE3AMEN1KMT2A | |
| SCHEMBL844890 | 0.75 | KCNH2 (0.51) | LMNAMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL845099 | 0.75 | ITGB1 (0.44) | PDE3BPDE3ALMNAKMT2AMAPT | |
| SCHEMBL845098 | 0.74 | ITGB1 (0.43) | PDE3BPDE3ALMNAKMT2ARAB9A | |
| SCHEMBL845190 | 0.72 | EPHX2 (0.42) | EPHX2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL845086 | 0.72 | EPHX2 (0.40) | EPHX2MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |