Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844741 | 0.94 | ITGB1 (0.39) | ITGB1ITGA4NAMPTRAB9APDE3B | |
| SCHEMBL845097 | 0.87 | NAMPT (0.39) | ITGB1ITGA4NAMPTRAB9APDE3B | |
| SCHEMBL845328 | 0.82 | NAMPT (0.35) | ITGB1ITGA4NAMPTRAB9APDE3B | |
| SCHEMBL845099 | 0.82 | ITGB1 (0.44) | ITGB1ITGA4PDE3BPDE3AKDM4E | |
| SCHEMBL845331 | 0.81 | PTPN1 (0.41) | NAMPTRAB9AKDM4EMEN1KMT2A | |
| SCHEMBL845098 | 0.81 | ITGB1 (0.43) | ITGB1ITGA4RAB9APDE3BPDE3A | |
| SCHEMBL845190 | 0.79 | EPHX2 (0.42) | ITGB1ITGA4RAB9AMEN1KMT2A | |
| SCHEMBL845622 | 0.78 | ITGB1 (0.42) | ITGB1ITGA4NAMPTPDE3BALDH1A1 | |
| SCHEMBL845086 | 0.78 | EPHX2 (0.40) | ITGB1ITGA4RAB9AKDM4EMEN1 | |
| SCHEMBL13272437 | 0.78 | ITGB1 (0.32) | ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |