Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845190 | 0.96 | EPHX2 (0.42) | EPHX2ITGB1ITGA4CYP3A4MEN1 | |
| SCHEMBL845334 | 0.88 | ITGB1 (0.39) | EPHX2ITGB1ITGA4CYP3A4MEN1 | |
| SCHEMBL10119279 | 0.88 | EPHX2 (0.37) | EPHX2ITGB1ITGA4CYP3A4MEN1 | |
| SCHEMBL845441 | 0.88 | GAA (0.43) | EPHX2ITGB1ITGA4CYP3A4KDM4E | |
| SCHEMBL845098 | 0.83 | ITGB1 (0.43) | ITGB1ITGA4HPGDKMT2ACA1 | |
| SCHEMBL845097 | 0.82 | NAMPT (0.39) | EPHX2ITGB1ITGA4MEN1KMT2A | |
| SCHEMBL845351 | 0.82 | ITGB1 (0.41) | ITGB1ITGA4KMT2AMAPTALDH1A1 | |
| SCHEMBL10119337 | 0.81 | ADRB1 (0.36) | EPHX2ITGB1ITGA4CYP3A4HTR1A | |
| SCHEMBL845393 | 0.80 | GAA (0.47) | EPHX2CYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL845099 | 0.79 | ITGB1 (0.44) | ITGB1ITGA4HPGDKMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |