SCHEMBL845475

SCHEMBL845475

COCC(=O)N1CCC[C@H]1C(=O)Nc1ccc(/C=C/c2ccc(NC(=O)[C@@H]3CCCN3C(=O)c3cccnc3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.44
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
VNN1 O95497 1/20 0.43
MAPK1 P28482 2/20 0.42
ALDH1A1 P00352 1/20 0.42
HTT P42858 1/20 0.42
DPP4 P27487 1/20 0.41
PREP P48147 1/20 0.41
FAP Q12884 1/20 0.41
DPP8 Q6V1X1 1/20 0.41
DPP9 Q86TI2 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
RHOC P08134 1/20 0.41
RHOA P61586 1/20 0.41
TRPV1 Q8NER1 1/20 0.41
LMNA P02545 2/20 0.40
NPC1 O15118 1/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL844960 0.90 DPP4 (0.43) ROCK2CYP2C9CYP2C19VNN1ALDH1A1
SCHEMBL872436 0.90 DPP4 (0.43) ROCK2CYP2C9CYP2C19VNN1ALDH1A1
SCHEMBL845297 0.90 RHOC (0.48) ROCK2CYP2C9CYP2C19VNN1MAPK1
SCHEMBL845231 0.89 HCRTR1 (0.43) ROCK2CYP2C9CYP2C19VNN1ALDH1A1
SCHEMBL845206 0.86 CYP2C9 (0.52) CYP2C9CYP2C19MAPK1ALDH1A1HTT
SCHEMBL845461 0.85 PREP (0.44) ROCK2CYP2C9CYP2C19VNN1PREP
SCHEMBL845234 0.85 RHOC (0.43) ROCK2CYP2C9CYP2C19VNN1ALDH1A1
SCHEMBL845478 0.82 NPC1 (0.43) ROCK2CYP2C9CYP2C19MAPK1ALDH1A1
SCHEMBL10119294 0.82 ITGB3 (0.41) ROCK2VNN1ALDH1A1DPP4PREP
SCHEMBL845338 0.79 RHOC (0.48) ROCK2CYP2C9CYP2C19ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8143288-B2 Inhibitors of HCV replication BRISTOL-MYERS SQUIBB COMPANY (US) 2012-03-27 US disclosed
US-8143288-B2 Inhibitors of HCV replication BRISTOL-MYERS SQUIBB COMPANY (US) 2012-03-27 US disclosed
EP-1893573-B1 INHIBITORS OF HCV REPLICATION BRISTOL MYERS SQUIBB CO (US) 2010-07-21 EP disclosed