Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845685 | 0.93 | TP53BP1 (0.46) | TP53BP1KDM4ELMNAPABPC1ALDH1A1 | |
| SCHEMBL13272513 | 0.87 | CFTR (0.38) | TP53BP1KDM4ELMNAPABPC1ALDH1A1 | |
| SCHEMBL13272494 | 0.87 | TP53BP1 (0.38) | TP53BP1KDM4ELMNAPABPC1ALDH1A1 | |
| SCHEMBL845048 | 0.82 | DGAT1 (0.50) | KDM4ELMNAPABPC1ALDH1A1RHOC | |
| SCHEMBL845405 | 0.82 | TRPV1 (0.46) | KDM4ERHOCRHOARXFP1CYP2C9 | |
| SCHEMBL845935 | 0.81 | PABPC1 (0.44) | TP53BP1KDM4ELMNAPABPC1ALDH1A1 | |
| SCHEMBL845250 | 0.78 | HCRTR1 (0.46) | TP53BP1KDM4ELMNAPABPC1ALDH1A1 | |
| SCHEMBL845333 | 0.78 | PABPC1 (0.48) | KDM4ELMNAPABPC1ALDH1A1RHOC | |
| SCHEMBL845070 | 0.78 | TRPV1 (0.44) | KDM4ELMNAPABPC1ALDH1A1RHOC | |
| SCHEMBL845007 | 0.77 | PABPC1 (0.49) | KDM4ELMNAPABPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |