Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845048 | 0.87 | DGAT1 (0.50) | DGAT1RHOCRHOANPC1SMN1; SMN2 | |
| SCHEMBL13272258 | 0.86 | TRPV1 (0.38) | TRPV1DGAT1KMT2ARHOCRHOA | |
| SCHEMBL845297 | 0.84 | RHOC (0.48) | TRPV1RHOCRHOANPC1SMN1; SMN2 | |
| SCHEMBL844934 | 0.83 | RHOC (0.51) | TRPV1KMT2ARHOCRHOANPC1 | |
| SCHEMBL844963 | 0.83 | DGAT1 (0.47) | DGAT1NPC1SMN1; SMN2KDM4ECYP2C9 | |
| SCHEMBL845570 | 0.82 | TP53BP1 (0.45) | RHOCRHOARXFP1KDM4ECYP2C9 | |
| SCHEMBL845725 | 0.82 | RHOC (0.45) | DGAT1RHOCRHOANPC1CYP2C9 | |
| SCHEMBL845070 | 0.81 | TRPV1 (0.44) | TRPV1RHOCRHOANPC1KDM4E | |
| SCHEMBL845338 | 0.80 | RHOC (0.48) | KMT2ARHOCRHOANPC1CYP2C9 | |
| SCHEMBL873200 | 0.79 | RHOC (0.48) | KMT2ARHOCRHOANPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |