Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844963 | 0.93 | DGAT1 (0.47) | DGAT1CYP2C9CYP2C19PABPC1ALDH1A1 | |
| SCHEMBL845250 | 0.91 | HCRTR1 (0.46) | DGAT1CYP2C9CYP2C19PABPC1ALDH1A1 | |
| SCHEMBL845935 | 0.90 | PABPC1 (0.44) | DGAT1CYP2C9CYP2C19PABPC1ALDH1A1 | |
| SCHEMBL845643 | 0.89 | MAPK1 (0.50) | DGAT1CYP2C9CYP2C19PABPC1ALDH1A1 | |
| SCHEMBL845405 | 0.87 | TRPV1 (0.46) | DGAT1CYP2C9CYP2C19HTTMAPT | |
| SCHEMBL13272265 | 0.86 | DGAT1 (0.41) | DGAT1CYP2C9CYP2C19PABPC1ALDH1A1 | |
| SCHEMBL13272381 | 0.84 | PABPC1 (0.40) | DGAT1CYP2C9CYP2C19PABPC1ALDH1A1 | |
| SCHEMBL4924225 | 0.84 | L3MBTL1 (0.50) | DGAT1 | |
| SCHEMBL4924222 | 0.84 | L3MBTL1 (0.50) | DGAT1 | |
| SCHEMBL845442 | 0.83 | CYP2C9 (0.43) | CYP2C9CYP2C19PABPC1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |