Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQOR | Q9Y6N5 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.34 |
| ▸ | RPS27 | P42677 | 4/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846353 | 0.73 | ALDH1A1 (0.38) | SQORALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28514735 | 0.71 | MRGPRX4 (0.45) | ALDH1A1CYP1A2CYP3A4CYP2C19MAOB | |
| SCHEMBL21226761 | 0.70 | SQOR (0.46) | SQORALDH1A1CNR1MAOBMAPK1 | |
| SCHEMBL845509 | 0.70 | SQOR (0.46) | SQORALDH1A1CNR1MAOBMAPK1 | |
| SCHEMBL9539690 | 0.69 | NPC1 (0.43) | ALDH1A1 | |
| SCHEMBL845322 | 0.68 | SQOR (0.44) | SQORALDH1A1CNR1MAOBCSF1R | |
| SCHEMBL846233 | 0.67 | SQOR (0.45) | SQORALDH1A1CYP1A2CYP2C19PDE10A | |
| SCHEMBL846782 | 0.67 | SQOR (0.43) | SQORRPS27MAOB | |
| SCHEMBL23174837 | 0.66 | KAT6A (0.38) | ALDH1A1CYP1A2CYP3A4MAPK1 | |
| SCHEMBL3759281 | 0.66 | SQOR (0.38) | SQORALDH1A1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |