Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560947 | 0.97 | TSHR (0.44) | TSHRGGPS1FAAHTRPV1THRB | |
| SCHEMBL11409740 | 0.97 | TSHR (0.44) | TSHRGGPS1FAAHTRPV1THRB | |
| SCHEMBL9543818 | 0.97 | TSHR (0.44) | TSHRGGPS1FAAHTRPV1THRB | |
| SCHEMBL15929348 | 0.97 | TSHR (0.44) | TSHRGGPS1FAAHTRPV1THRB | |
| SCHEMBL11416194 | 0.97 | TSHR (0.44) | TSHRGGPS1FAAHTRPV1THRB | |
| SCHEMBL2320588 | 0.92 | TSHR (0.39) | TSHRTHRBALDH1A1 | |
| SCHEMBL3654899 | 0.80 | — | — | |
| SCHEMBL28542877 | 0.80 | TSHR (0.37) | TSHRGGPS1FAAHTRPV1THRB | |
| SCHEMBL8350454 | 0.77 | TSHR (0.39) | TSHRGGPS1FAAHTRPV1THRB | |
| SCHEMBL27481524 | 0.77 | TSHR (0.39) | TSHRGGPS1FAAHTRPV1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318502-A1 | Pharmaceutical Compositions Comprising a Hypoglycemic Agent and Methods of Using Same | INTRANASAL THERAPEUTICS, INC. (US) | 2009-12-24 | — | — | US | claimed |
| WO-2007111933-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A HYPOGLYCEMIC AGENT AND METHODS OF USING SAME | INTRANASAL THERAPEUTICS , INC. (US) | 2007-10-04 | — | — | WO | claimed |
| US-20020082426-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-06-27 | — | — | US | claimed |
| EP-1086083-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-09-26 | — | — | EP | claimed |
| EP-1086083-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064399-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-16 | — | — | WO | claimed |
| US-5180836-A | Antiulcer agents | NIPPON CHEMIPHAR CO., LTD. (JP) | 1993-01-19 | — | — | US | claimed |
| US-5082943-A | Antiulcer | NIPPON CHEMIPHAR CO., LTD. (JP) | 1992-01-21 | — | — | US | claimed |
| CN-113999158-B | 3- (1-hydroxyalkylene) indolone and preparation method thereof | 延边大学 | 2023-08-01 | — | — | CN | disclosed |
| EP-4028130-A1 | BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION | Shionogi & Co., Ltd (JP) | 2022-07-20 | — | — | EP | disclosed |
| WO-2021050708-A1 | BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION | SHIONOGI & CO., LTD. (JP) | 2021-03-18 | — | — | WO | disclosed |
| EP-3784248-A2 | EXON SKIPPING OLIGOMERS AND OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY | Sarepta Therapeutics, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-3252069-B1 | (11.BETA.,17.BETA.)-17-HYDROXY-11-[4-(METHYLSULFONYL)PHENYL]-17-(PENTALFUOROMETHYL)ESTRA-4,9-DIEN-3-ONE FOR USE IN THE TREATMENT OF DISEASES | Bayer Pharma AG (DE) | 2019-04-03 | — | — | EP | disclosed |
| EP-2534155-B1 | COMPOUNDS FOR TREATING RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENT MANAGEMENT PTY LTD (AU) | 2018-04-11 | — | — | EP | disclosed |
| WO-1991019733-A1 | DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS | ABBOTT LABORATORIES (US) | 1991-12-26 | — | — | WO | disclosed |
| EP-0415103-A1 | 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-06 | — | — | EP | disclosed |
| EP-0129582-A4 | ORALLY ADMINISTERED BIOLOGICALLY ACTIVE PEPTIDES AND PROTEINS. | RESEARCH CORP (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4582820-A | Orally administered biologically active peptides and proteins | RESEARCH CORPORATION (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0129582-A1 | ORALLY ADMINISTERED BIOLOGICALLY ACTIVE PEPTIDES AND PROTEINS | University of Washington (US) | 1985-01-02 | — | — | EP | disclosed |
| WO-1984002467-A1 | ORALLY ADMINISTERED BIOLOGICALLY ACTIVE PEPTIDES AND PROTEINS | RESEARCH CORP (US) | 1984-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082426-A1 | Protease inhibitors | CTSK, CTSZ, CTSB | TSHR 4341/4885GGPS1 2322/4885FAAH 762/4885 |
| US-20090318502-A1 | Pharmaceutical Compositions Comprising a Hypoglycemic Agent and Methods of Using Same | IAPP, GPR119, SLC5A2 | TSHR 3402/4885GGPS1 2387/4885FAAH 3150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.