Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402176 | 0.88 | USP2 (0.44) | PSMB8PSMB5USP2ITGB3ITGA2B | |
| SCHEMBL8801722 | 0.85 | MMP1 (0.44) | PSMB8PSMB5USP2ITGB3ITGA2B | |
| SCHEMBL7487574 | 0.80 | ITGB3 (0.48) | ITGB3ITGA2BITGAVNPC1RAB9A | |
| SCHEMBL7484657 | 0.79 | ITGB3 (0.48) | ITGB3ITGA2BCA9CA1CA2 | |
| SCHEMBL7912610 | 0.78 | F2 (0.42) | ITGB3ITGA2BCA2ITGAV | |
| SCHEMBL7920933 | 0.77 | ITGB3 (0.47) | ITGB3ITGA2BCA9CA1CA2 | |
| SCHEMBL8458587 | 0.77 | SLC1A3 (0.47) | SLC1A3SLC1A2SLC1A1ITGB3ITGA2B | |
| SCHEMBL8801713 | 0.76 | SLC1A2 (0.55) | SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7398408 | 0.76 | ITGB3 (0.50) | PSMB8PSMB5USP2ITGB3ITGA2B | |
| SCHEMBL8456795 | 0.76 | HSD17B10 (0.39) | MMP2RAB9AGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929120-A | Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5741796-A | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption | MERCK & CO., INC. (US) | 1998-04-21 | — | — | US | disclosed |