Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.39 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6385791 | 0.79 | TRPV1 (0.37) | TRPV1RAB9AMEN1NPC1ALDH1A1 | |
| SCHEMBL6388617 | 0.75 | TRPV1 (0.42) | TRPV1RAB9ALMNAPOLBTSHR | |
| SCHEMBL6384532 | 0.74 | TRPV1 (0.41) | TRPV1RAB9ALMNAPOLBTSHR | |
| SCHEMBL6382503 | 0.73 | TRPV1 (0.51) | TRPV1 | |
| Hydrochloric Acid SCHEMBL8829056 | 0.73 | RAB9A (0.42) | TRPV1RAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL846491 | 0.72 | TRPV1 (0.71) | TRPV1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL846426 | 0.72 | RXRA (0.47) | TRPV1RAB9ALMNAPOLBTSHR | |
| SCHEMBL845852 | 0.71 | MEN1 (0.57) | TRPV1RAB9AMEN1NPC1ALDH1A1 | |
| SCHEMBL846632 | 0.70 | DAGLA (0.42) | RAB9AMEN1NPC1KMT2ALMNA | |
| SCHEMBL13616 | 0.69 | KDR (0.44) | RAB9ANPC1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |