Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SI | P14410 | 2/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.36 |
| ▸ | CCR8 | P51685 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383681 | 0.87 | DAGLA (0.38) | DAGLAKCNH2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL846426 | 0.78 | RXRA (0.47) | MGAMRAB9ALMNAPOLBTSHR | |
| Hydrochloric Acid SCHEMBL8829056 | 0.75 | RAB9A (0.42) | KMT2AMGAMRAB9ALMNAPOLB | |
| SCHEMBL6388617 | 0.72 | TRPV1 (0.42) | MGAMRAB9ALMNAPOLBTSHR | |
| SCHEMBL845990 | 0.71 | MEN1 (0.53) | MEN1KMT2APOLBCTSBMAPT | |
| SCHEMBL845853 | 0.70 | TRPV1 (0.46) | MEN1KMT2ARAB9ALMNAPOLB | |
| SCHEMBL13616 | 0.69 | KDR (0.44) | KMT2AMGAMRAB9ALMNAPOLB | |
| SCHEMBL6384532 | 0.67 | TRPV1 (0.41) | MGAMRAB9ALMNAPOLBTSHR | |
| SCHEMBL20288621 | 0.66 | PIK3CA (0.49) | — | |
| SCHEMBL6383676 | 0.64 | TRPV1 (0.41) | MGAMRAB9ALMNAPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |