Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552472 | 0.84 | TSHR (0.64) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL8534214 | 0.82 | TSHR (0.57) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL2255355 | 0.79 | TSHR (0.63) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL5990135 | 0.78 | TSHR (0.61) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL28049900 | 0.77 | L3MBTL1 (0.62) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL29394053 | 0.76 | CES2 (0.53) | ALDH1A1POLBLMNANPSR1 | |
| SCHEMBL5158714 | 0.76 | TSHR (0.59) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL28481770 | 0.76 | TSHR (0.59) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL2598225 | 0.76 | TSHR (0.59) | TSHRALDH1A1MAPK1GSK3BTRPA1 | |
| SCHEMBL8898345 | 0.76 | TSHR (0.59) | TSHRALDH1A1MAPK1GSK3BTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |