Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.54 |
| ▸ | RARA | P10276 | 3/20 | 0.54 |
| ▸ | RARB | P10826 | 2/20 | 0.54 |
| ▸ | RARG | P13631 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | BLVRB | P30043 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9060654 | 0.83 | ALDH1A1 (0.54) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL16607007 | 0.80 | ALDH1A1 (0.69) | KMT2AMEN1MITFFFAR1NR1H4 | |
| SCHEMBL28419632 | 0.78 | MITF (0.81) | KMT2AMEN1MITFFFAR1HPSE | |
| SCHEMBL900903 | 0.78 | MITF (0.81) | KMT2AMEN1MITFFFAR1HPSE | |
| SCHEMBL8827340 | 0.78 | MITF (0.81) | KMT2AMEN1MITFFFAR1HPSE | |
| SCHEMBL8462054 | 0.78 | NR1H4 (0.59) | KMT2AMEN1HPSENR1H4KCNK3 | |
| SCHEMBL16583885 | 0.77 | RAB9A (0.79) | KMT2AMEN1MITFCYP3A4CYP26A1 | |
| SCHEMBL2755400 | 0.77 | ALDH1A1 (0.56) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL12164873 | 0.76 | NR1H4 (0.59) | KMT2AMEN1CYP3A4NR1H4RAB9A | |
| SCHEMBL6781232 | 0.76 | KCNK3 (0.72) | KMT2AMEN1KCNK3KCNK9RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |