Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.69 |
| ▸ | RXRB | P28702 | 9/20 | 0.69 |
| ▸ | RXRG | P48443 | 7/20 | 0.69 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460355 | 0.86 | RXRA (0.74) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL8458553 | 0.84 | RXRA (0.65) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL5030365 | 0.83 | RXRA (0.72) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL3237142 | 0.83 | MRGPRX4 (0.54) | RXRARXRBRXRGMRGPRX4SMN1; SMN2 | |
| SCHEMBL7766099 | 0.82 | WDR5 (0.47) | RXRARXRBRXRGMRGPRX4NPC1 | |
| SCHEMBL6238028 | 0.82 | RXRA (1.00) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL8460108 | 0.80 | RXRA (0.76) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL8461702 | 0.78 | RXRA (0.70) | RXRARXRBRXRGMRGPRX4NR4A2 | |
| SCHEMBL5321778 | 0.77 | PTGDR2 (0.70) | MRGPRX4SMN1; SMN2 | |
| SCHEMBL8908814 | 0.77 | RXRA (0.63) | RXRARXRBRXRGMRGPRX4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |