Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | ESR1 | P03372 | 11/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684447 | 0.85 | TGM2 (0.72) | TGM2CYP19A1ALDH1A1RAB9A | |
| SCHEMBL13586721 | 0.80 | TGM2 (0.64) | TGM2CYP19A1ALDH1A1RAB9A | |
| SCHEMBL8456134 | 0.79 | ACACB (0.49) | PTGS2ESR1ESR2PGRCYP19A1 | |
| SCHEMBL39036 | 0.79 | TGM2 (0.72) | TGM2ALDH1A1HPGDRAB9A | |
| SCHEMBL10773604 | 0.76 | PTGS2 (0.60) | PTGS2ESR1ESR2PGRCYP19A1 | |
| SCHEMBL81209 | 0.75 | TGM2 (1.00) | TGM2 | |
| SCHEMBL641477 | 0.74 | ESR1 (0.80) | PTGS2ESR1ESR2PGRCYP19A1 | |
| Diethylamine SCHEMBL1262240 | 0.74 | TGM2 (0.76) | TGM2ALDH1A1 | |
| SCHEMBL7238545 | 0.74 | ESR1 (0.68) | PTGS2ESR1ESR2PGRCYP19A1 | |
| SCHEMBL7238542 | 0.74 | ESR1 (0.68) | PTGS2ESR1ESR2PGRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681835-A | USEFUL FOR TREATING OSTEOPOROSIS | GLAXO WELLCOME INC. (US) | 1997-10-28 | — | — | US | claimed |
| US-5877219-A | Non-steroidal ligands for the estrogen receptor | GLAXO WELLCOMEINC. (US) | 1999-03-02 | — | — | US | disclosed |
| US-5681835-A | USEFUL FOR TREATING OSTEOPOROSIS | GLAXO WELLCOME INC. (US) | 1997-10-28 | — | — | US | disclosed |