Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31614294 | 0.83 | MT-CO2 (0.55) | FOLH1KMT2AMEN1GAAESR1 | |
| SCHEMBL27640937 | 0.83 | MT-CO2 (0.55) | FOLH1KMT2AMEN1GAAESR1 | |
| SCHEMBL18890086 | 0.82 | LMNA (0.41) | FOLH1KMT2AMEN1LMNANPSR1 | |
| SCHEMBL7069500 | 0.80 | FOLH1 (0.50) | FOLH1KMT2AMEN1GAAESR1 | |
| SCHEMBL29234606 | 0.79 | KIF11 (0.38) | FOLH1KMT2AMEN1ESR1ESR2 | |
| SCHEMBL27965732 | 0.78 | FOLH1 (0.49) | FOLH1KMT2AMEN1NR3C1PGR | |
| SCHEMBL1564938 | 0.77 | CYP1A2 (0.50) | KMT2AMEN1LMNANPSR1 | |
| SCHEMBL8881032 | 0.77 | ESR1 (0.54) | KMT2AESR1LMNAALOX15ESR2 | |
| SCHEMBL12607235 | 0.76 | TSHR (0.45) | KMT2AMEN1GAAESR1LMNA | |
| SCHEMBL30523061 | 0.75 | KMT2A (0.46) | KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906315-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049710-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-12-31 | — | — | WO | disclosed |