Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2419793 | 0.90 | ALDH1A1 (0.68) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM | |
| SCHEMBL10938127 | 0.87 | DHODH (0.51) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM | |
| SCHEMBL29190958 | 0.81 | HTT (0.73) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM | |
| SCHEMBL29190948 | 0.81 | SMN1; SMN2 (0.65) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM | |
| SCHEMBL29190961 | 0.81 | SMN1; SMN2 (0.69) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM | |
| SCHEMBL23452267 | 0.80 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM | |
| SCHEMBL1127328 | 0.78 | NOTUM (0.70) | RAB9AALDH1A1GAAMAPTNOTUM | |
| SCHEMBL232724 | 0.78 | RAB9A (0.74) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL29190947 | 0.78 | RAB9A (0.60) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM | |
| SCHEMBL29191041 | 0.78 | SMN1; SMN2 (0.64) | RAB9ASMN1; SMN2NPC1HSP90AA1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859042-A | ALOPECIA, ACNE, DISEASES OF THE PROSTATE GLANDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | claimed |
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |