Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10939397 | 0.90 | ALDH1A1 (0.58) | ATMALDH1A1KMORAB9ANPC1 | |
| SCHEMBL8460916 | 0.87 | RAB9A (0.63) | DHODHCDC25BATMALDH1A1EGFR | |
| SCHEMBL10941178 | 0.83 | EGFR (0.52) | ALDH1A1EGFRMAPTGAAAXL | |
| SCHEMBL10944870 | 0.81 | POLB (0.51) | ALDH1A1RAB9ANPC1HSP90AA1PKM | |
| SCHEMBL10936789 | 0.81 | SRD5A2 (0.58) | ALDH1A1RAB9ANPC1HSP90AA1PKM | |
| SCHEMBL10938851 | 0.81 | HTT (0.64) | ALDH1A1RAB9ANPC1HSP90AA1PKM | |
| SCHEMBL10936402 | 0.80 | MEN1 (0.49) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL28870296 | 0.77 | SRD5A2 (0.65) | DHODHCDC25BATMALDH1A1EGFR | |
| SCHEMBL14075236 | 0.76 | SRD5A2 (0.77) | CDC25BATMALDH1A1EGFRRAB9A | |
| SCHEMBL23671728 | 0.76 | DHODH (0.81) | DHODHEGFRKMOSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |