SCHEMBL8463296

SCHEMBL8463296

C=C(C)C(=C)C.C[Ti](C)(NC(=O)C1CCCCCCCCCCC1)C1c2ccccc2-c2ccccc21.[SiH4]

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
HPGD P15428 1/20 0.40
HDAC1 Q13547 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC3 O15379 1/20 0.39
P2RX7 Q99572 2/20 0.38
ALDH1A1 P00352 4/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
CETP P11597 1/20 0.36
KMT2A Q03164 1/20 0.36
KDM4E B2RXH2 2/20 0.36
TSHR P16473 1/20 0.36
HTT P42858 1/20 0.36
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butadiene SCHEMBL8463476 0.90 CYP2C19 (0.41) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL8465641 0.90 HPGD (0.40) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL8463320 0.90 CYP2C19 (0.39) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL7743272 0.83 CYP2C19 (0.41) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL8008148 0.83 CYP2C19 (0.41) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL8677152 0.79 SMN1; SMN2 (0.37) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL6471494 0.79 KMT2A (0.38) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL8463303 0.77 KMT2A (0.40) HPGDHDAC1HDAC2HDAC3ALDH1A1
SCHEMBL6465538 0.74 ALDH1A1 (0.41) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2
SCHEMBL8678235 0.73 CYP2C19 (0.41) CYP2C19SMN1; SMN2HPGDHDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767795-B1 GROUP 4 METAL DIENE COMPLEXES AND ADDITION POLYMERIZATION CATALYSTS THEREFROM DOW CHEMICAL CO (US) 1999-12-22 EP disclosed
US-5770538-A Group 4 metal diene complexes and addition polymerization catalysts therefrom THE DOW CHEMICAL COMPANY (US) 1998-06-23 US disclosed
EP-0767795-A1 GROUP 4 METAL DIENE COMPLEXES AND ADDITION POLYMERIZATION CATALYSTS THEREFROM THE DOW CHEMICAL COMPANY (US) 1997-04-16 EP disclosed
US-5539068-A Group 4, metal-conjugated diene metallocyclopentene complexes, and addition polymerization catalysts therefrom THE DOW CHEMICAL COMPANY (US) 1996-07-23 US disclosed
US-5486632-A Group 4 metal diene complexes and addition polymerization catalysts therefrom THE DOW CHEMICAL COMPANY (US) 1996-01-23 US disclosed
WO-1996000734-A1 GROUP 4 METAL DIENE COMPLEXES AND ADDITION POLYMERIZATION CATALYSTS THEREFROM THE DOW CHEMICAL COMPANY (US) 1996-01-11 WO disclosed