Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9353090 | 0.87 | KMT2A (0.52) | NPC1POLBMAPK1MAPTALDH1A1 | |
| SCHEMBL9353097 | 0.84 | NPC1 (0.44) | NPC1POLBMAPTALDH1A1MEN1 | |
| SCHEMBL8467038 | 0.83 | ALDH1A1 (0.52) | POLBALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7223364 | 0.82 | POLB (0.45) | NPC1POLBALDH1A1MEN1KMT2A | |
| SCHEMBL7230766 | 0.81 | POLB (0.42) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9357235 | 0.81 | TSHR (0.49) | POLBMAPK1MAPTALDH1A1MEN1 | |
| SCHEMBL9357242 | 0.81 | TSHR (0.49) | POLBMAPK1MAPTALDH1A1MEN1 | |
| SCHEMBL1201738 | 0.80 | AKR1B1 (0.60) | NPC1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9617428 | 0.79 | NPC1 (0.47) | NPC1POLBMAPK1MAPTALDH1A1 | |
| SCHEMBL7225323 | 0.78 | HDAC3 (0.42) | POLBMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469888-B1 | Amidobenzenes | ICI PLC (GB) | 1994-09-28 | — | — | EP | claimed |
| EP-0469888-A1 | Amidobenzenes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-05 | — | — | EP | claimed |
| US-5866578-A | Substituted pyrimidines for control of diabetic complications | PFIZER INC (US) | 1999-02-02 | — | — | US | disclosed |
| US-5728704-A | INHIBITS SORBITOL DEHYDROGENASE | PFIZER INC. (US) | 1998-03-17 | — | — | US | disclosed |
| EP-0662962-A1 | SUBSTITUTED PYRIMIDINES FOR CONTROL OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1995-07-19 | — | — | EP | disclosed |
| EP-0469888-B1 | Amidobenzenes | ICI PLC (GB) | 1994-09-28 | — | — | EP | disclosed |
| WO-1994007867-A1 | SUBSTITUTED PYRIMIDINES FOR CONTROL OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5250570-A | Aldose reductase inhibitors for controlling side effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-05 | — | — | US | disclosed |
| EP-0469888-A1 | Amidobenzenes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-05 | — | — | EP | disclosed |