Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592058 | 0.88 | ALDH1A1 (0.32) | MAPT | |
| SCHEMBL8958053 | 0.88 | CA12 (0.40) | MAPTSMN1; SMN2 | |
| SCHEMBL7223994 | 0.87 | POLB (0.36) | MAPT | |
| SCHEMBL8957820 | 0.83 | THRA (0.38) | MAPTSMN1; SMN2 | |
| SCHEMBL8957815 | 0.82 | ALDH1A1 (0.33) | MAPTSMN1; SMN2 | |
| SCHEMBL8958011 | 0.82 | POLB (0.33) | MAPTSMN1; SMN2 | |
| SCHEMBL7228473 | 0.82 | MAPT (0.40) | MAPTSMN1; SMN2 | |
| SCHEMBL7223364 | 0.80 | POLB (0.45) | — | |
| SCHEMBL7225299 | 0.80 | ALDH1A1 (0.43) | MAPTSMN1; SMN2 | |
| SCHEMBL8957970 | 0.80 | CA12 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | claimed |
| US-5866578-A | Substituted pyrimidines for control of diabetic complications | PFIZER INC (US) | 1999-02-02 | — | — | US | disclosed |
| US-5728704-A | INHIBITS SORBITOL DEHYDROGENASE | PFIZER INC. (US) | 1998-03-17 | — | — | US | disclosed |
| EP-0662962-A1 | SUBSTITUTED PYRIMIDINES FOR CONTROL OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007867-A1 | SUBSTITUTED PYRIMIDINES FOR CONTROL OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| US-5189031-A | Inhibitor of enzyme aldose reductase, useful in the treatment of certain peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5110808-A | Aldose reductase inhibitors; peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1992-05-05 | — | — | US | disclosed |