Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.33 |
| ▸ | MEN1 | O00255 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223994 | 0.92 | POLB (0.36) | POLBKMT2AMEN1MAPTRAB9A | |
| SCHEMBL8958259 | 0.89 | RAB9A (0.34) | POLBKMT2AMEN1MAPTRAB9A | |
| SCHEMBL8957820 | 0.88 | THRA (0.38) | KMT2AMEN1MAPTRAB9AAKR1B1 | |
| SCHEMBL8957815 | 0.86 | ALDH1A1 (0.33) | POLBKMT2AMEN1MAPTRAB9A | |
| SCHEMBL7228473 | 0.86 | MAPT (0.40) | POLBKMT2AMEN1MAPTRAB9A | |
| SCHEMBL7225299 | 0.85 | ALDH1A1 (0.43) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL7223364 | 0.85 | POLB (0.45) | POLBKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL9592058 | 0.84 | ALDH1A1 (0.32) | POLBKMT2AMEN1MAPTRAB9A | |
| SCHEMBL7230766 | 0.83 | POLB (0.42) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL8464375 | 0.82 | MAPT (0.31) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5189031-A | Inhibitor of enzyme aldose reductase, useful in the treatment of certain peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5110808-A | Aldose reductase inhibitors; peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1992-05-05 | — | — | US | disclosed |
| EP-0469889-A1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |