Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27302478 | 0.88 | ABCB1 (0.54) | HTR1AADRA1DADRA1AADRA1BTAAR1 | |
| SCHEMBL7062037 | 0.82 | HTR2A (0.48) | SIGMAR1HTR2A | |
| SCHEMBL3606088 | 0.81 | POLB (0.48) | HTR2A | |
| SCHEMBL29463722 | 0.81 | SIGMAR1 (0.65) | SIGMAR1HTR2ATAAR1ABCB1 | |
| SCHEMBL9571819 | 0.81 | SIGMAR1 (0.65) | SIGMAR1HTR2ATAAR1ABCB1 | |
| SCHEMBL28880178 | 0.79 | NR3C1 (0.43) | SIGMAR1HTR2A | |
| SCHEMBL27528098 | 0.79 | HTR2A (0.42) | HTR1AADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL3728677 | 0.78 | LTA4H (0.52) | HTR1AADRA1DADRA1AADRA1BTAAR1 | |
| SCHEMBL6898660 | 0.78 | ALOX5 (0.53) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8464775 | 0.77 | HPGD (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682662-B1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 1999-08-18 | — | — | EP | disclosed |
| CN-1117290-A | Bicyclic carboxylic acid leukotriene B4 antagonists | HOFFMANN LA ROCHE (CH) | 1996-02-21 | — | — | CN | disclosed |
| EP-0682662-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B 4? ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-22 | — | — | EP | disclosed |
| US-5457124-A | Antiinflammatory agent | HOFFMANN-LA ROCHE INC. (US) | 1995-10-10 | — | — | US | disclosed |
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| WO-1995015956-A1 | BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-15 | — | — | WO | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| CN-1071423-A | BICYCLIC CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1993-04-28 | — | — | CN | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |