Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27391157 | 0.98 | TDP1 (0.45) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| Tetraphenylphosphonium SCHEMBL27516717 | 0.87 | ATM (0.38) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| Diphenyl Ethanedioat SCHEMBL43364 | 0.85 | TDP1 (0.54) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| Potassium Ion SCHEMBL10359784 | 0.83 | TDP1 (0.48) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| Diphenyl Ethanedioat SCHEMBL27328178 | 0.82 | TDP1 (0.52) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| SCHEMBL131450 | 0.80 | TDP1 (0.50) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| SCHEMBL419381 | 0.80 | TDP1 (0.50) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| Diphenyl Ethanedioat SCHEMBL10797780 | 0.80 | TDP1 (0.50) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| Ethylene SCHEMBL11136085 | 0.79 | TDP1 (0.45) | TDP1ATML3MBTL1ALOX15HSD17B10 | |
| Methacrylic Acid SCHEMBL28606165 | 0.78 | ELANE (0.63) | TDP1ATML3MBTL1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5892091-A | PHOSPHOROUS CATALYSTS AND HALOGEN ATOMS | UBE INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0826658-A1 | Catalyst for decarbonylation reaction | UBE INDUSTRIES, LTD. (JP) | 1998-03-04 | — | — | EP | disclosed |