Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.63 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.63 |
| ▸ | S100A4 | P26447 | 2/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8466603 | 0.95 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1S100A4PTPRCMEN1 | |
| SCHEMBL8465017 | 0.90 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1S100A4PTPRCMEN1 | |
| SCHEMBL8465123 | 0.82 | S100A4 (0.46) | HSP90AA1HSP90AB1S100A4PTPRCKMT2A | |
| SCHEMBL8465262 | 0.80 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL8464963 | 0.80 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL1274825 | 0.78 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL8465211 | 0.78 | S100A4 (0.46) | HSP90AA1HSP90AB1S100A4PTPRCKMT2A | |
| SCHEMBL8464823 | 0.74 | S100A4 (0.42) | HSP90AA1HSP90AB1S100A4PTPRCKMT2A | |
| SCHEMBL8464939 | 0.74 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL8465103 | 0.74 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981544-A | Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof | LABORATOIRE INNOTHERA (FR) | 1999-11-09 | — | — | US | claimed |
| US-5981544-A | Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof | LABORATOIRE INNOTHERA (FR) | 1999-11-09 | — | — | US | disclosed |