SCHEMBL8465211

SCHEMBL8465211

O=C1c2cccc([N+](=O)[O-])c2C(=O)c2c1nc1ccc(Cl)cn21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.46
PTPRC P08575 1/20 0.43
LCK P06239 2/20 0.42
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
AURKA O14965 1/20 0.38
TP53 P04637 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 2/20 0.36
RECQL P46063 1/20 0.36
KMT2A Q03164 1/20 0.36
MCL1 Q07820 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
IDO1 P14902 1/20 0.36
TDO2 P48775 1/20 0.36
CSNK2A2 P19784 1/20 0.36
CSNK2B P67870 1/20 0.36
CSNK2A1 P68400 1/20 0.36
CSNK2A3 Q8NEV1 1/20 0.36
NR1I3 Q14994 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465123 0.95 S100A4 (0.46) S100A4PTPRCLCKHSP90AA1HSP90AB1
SCHEMBL8464968 0.91 S100A4 (0.43) S100A4PTPRCLCKHSP90AA1HSP90AB1
SCHEMBL8466603 0.82 HSP90AA1 (0.63) S100A4PTPRCHSP90AA1HSP90AB1KMT2A
SCHEMBL8466658 0.81 HSP90AA1 (0.44) HSP90AA1HSP90AB1TP53GAAMAPT
SCHEMBL8465227 0.79 HSP90AA1 (0.63) HSP90AA1HSP90AB1TP53GAAMAPT
SCHEMBL8464981 0.78 HSP90AA1 (0.63) S100A4PTPRCHSP90AA1HSP90AB1KMT2A
SCHEMBL8464922 0.76 HSP90AA1 (0.44) HSP90AA1HSP90AB1TP53GAAMAPT
SCHEMBL8464823 0.74 S100A4 (0.42) S100A4PTPRCLCKHSP90AA1HSP90AB1
SCHEMBL8468193 0.73 HSP90AA1 (0.51) S100A4HSP90AA1HSP90AB1TP53GAA
SCHEMBL8465017 0.73 HSP90AA1 (0.56) S100A4PTPRCHSP90AA1HSP90AB1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed