Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Meprobamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.89 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.89 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meprobamate SCHEMBL15286 | 0.94 | LMNA (1.00) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL3056097 | 0.94 | LMNA (1.00) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL8913202 | 0.92 | LMNA (0.96) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL7583576 | 0.92 | LMNA (0.96) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL29045066 | 0.92 | LMNA (0.96) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL18703920 | 0.92 | LMNA (0.96) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL341321 | 0.90 | LMNA (0.92) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL20545451 | 0.90 | LMNA (0.92) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL8081512 | 0.87 | LMNA (0.85) | LMNAHSD17B10TSHRCYP3A4NFKB1 | |
| Meprobamate SCHEMBL22712997 | 0.86 | LMNA (0.77) | LMNAHSD17B10TSHRCYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977147-A | ANTITUMOR | HOECHST MARION ROUSSEL (US) | 1999-11-02 | — | — | US | disclosed |