SCHEMBL8465356

SCHEMBL8465356

Cc1cc(Cl)c(C(=O)Cl)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD44 P16070 1/20 0.39
GPR27 Q9NS67 2/20 0.39
GRIN2D O15399 1/20 0.38
GRIN3B O60391 1/20 0.38
GRIN1 Q05586 1/20 0.38
GRIN2A Q12879 1/20 0.38
GRIN2B Q13224 1/20 0.38
GRIN2C Q14957 1/20 0.38
GRIN3A Q8TCU5 1/20 0.38
LMNA P02545 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.34
TSHR P16473 1/20 0.34
CASP1 P29466 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
MYC P01106 1/20 0.34
NR4A1 P22736 1/20 0.34
MCL1 Q07820 1/20 0.34
GABRA1 P14867 3/20 0.34
GABRG2 P18507 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10630611 0.91 CD44 (0.39) CD44GPR27GRIN2DGRIN3BGRIN1
SCHEMBL10630827 0.88 SMN1; SMN2 (0.35) SMN1; SMN2TSHRCASP1KDM4EMAPT
SCHEMBL7705491 0.86 SMN1; SMN2 (0.34) SMN1; SMN2TSHRCASP1KDM4EMAPT
SCHEMBL101268 0.85 TSHR (0.42) SMN1; SMN2TSHRCASP1KDM4EMAPT
SCHEMBL8340285 0.82 ALDH1A1 (0.48) GPR27LMNASMN1; SMN2TSHRCASP1
SCHEMBL10630755 0.81 ALDH1A1 (0.33) SMN1; SMN2TSHRCASP1KDM4EMAPT
SCHEMBL31255799 0.81 CD44 (0.56) CD44GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL1312984 0.80 TSHR (0.39) SMN1; SMN2TSHRCASP1KDM4EMAPT
SCHEMBL11807436 0.78 GAA (0.47) LMNASMN1; SMN2TSHRKDM4EMAPT
SCHEMBL9812995 0.78 TSHR (0.41) SMN1; SMN2TSHRCASP1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5969200-A CHLORINATING PARA-TOLUOYL CHLORIDE IN PRESENCE OF CHLORINE GAS AND ALUMINUM CHLORIDE OR ANTIMONY CHLORIDE CATALYST, DISTILLING MIXTURE PRODUCED TO RECOVER 3,5-DICHLORO-4-METHYLBENZOYL CHLORIDE ROHM AND HAAS COMPANY (US) 1999-10-19 US claimed
EP-0816328-A2 Process for the manufacture of acetonylbenzamides ROHM AND HAAS COMPANY (US) 1998-01-07 EP claimed
CN-120229998-A Novel preparation method of (4-chlorophenyl) (2, 6-dichloro-4-methylphenyl) methanone and carboxyamidotriazole intermediate 广东银珠医药科技有限公司 2025-07-01 CN disclosed
US-4762844-A ANIMAL GROWTH REGULATORS BAYER AKTIENGESELLSCHAFT (DE) 1988-08-09 US disclosed