Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4659130 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL4659191 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL8465872 | 0.87 | DRD2 (0.34) | DRD2 | |
| Hydrochloric Acid SCHEMBL8462257 | 0.82 | DRD2 (0.35) | KIF11DRD2 | |
| Hydrochloric Acid SCHEMBL8459038 | 0.81 | KIF11 (0.32) | KIF11DRD2BACE1 | |
| Hydrochloric Acid SCHEMBL8457804 | 0.81 | DRD2 (0.34) | DRD2 | |
| Hydrochloric Acid SCHEMBL8463874 | 0.81 | DRD2 (0.34) | DRD2 | |
| Hydrochloric Acid SCHEMBL8461390 | 0.81 | DRD2 (0.34) | DRD2 | |
| Hydrochloric Acid SCHEMBL8461606 | 0.81 | DRD2 (0.34) | DRD2 | |
| Hydrochloric Acid SCHEMBL8465321 | 0.81 | DRD2 (0.34) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859272-A | METALLOCENES; PRODUCES POLYOLEFINS HAVING A HIGH MELTING POINT AND A HIGH MOLECULAR WEIGHT; HIGH POLYMERIZATION ACTIVITY | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| US-5616663-A | TRANSITION METAL COMPOUND, ALUMINOXANE, COMPOUND WHICH REACTS WITH TRANSITION METAL COMPOUND TO FORM ION PAIR | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-01 | — | — | US | disclosed |